Synergism between trimethoprim and sulfamethoxazole
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منابع مشابه
Sulfamethoxazole-trimethoprim synergism for Neisseria gonorrhoeae.
Sulfamethoxazole and trimethoprim are synergistic against many bacteria in sulfamethoxazole/trimethoprim concentrations of 20:1, but single-dose therapy of gonorrhea with the combination is disappointing. We used agar dilution techniques to determine minimal inhibitory concentrations of sulfamethoxazole and trimethoprim for 168 gonococci isolated from men with acute urethritis in Atlanta, Ga. T...
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The sulfonamides were the first drugs with antituberculous effects. Their use was abandoned and basically forgotten with the advent of streptomycin and isoniazid combination treatment. There is a widespread belief, apparently based on testing a single isolate on questionable media, that Mycobacterium tuberculosis is resistant to trimethoprim-sulfamethoxazole (TMP-SMX). We saw a complex immunoco...
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famethoxazole remains a popular antibiotic because of its low cost, effectiveness and familiarity among clinicians. It is the most frequently prescribed antibiotic for urinary tract infections in Canada. Other indications include treatment of infections caused by Pneumocystis jiroveci, Toxoplasma gondii, Stenotrophomonas maltophilia and community-associated methicillin-resistant Staphylococcus ...
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The combination trimethoprim-sulfamethoxazole had no greater activity in a murine model of toxoplasmosis than did sulfamethoxazole alone.
متن کاملA MATHEMATICAL MODEL TO DESCRIBE THE SYNERGISTIC EFFECT BETWEEN SULFAMETHOXAZOLE AND TRIMETHOPRIM
b a s e don folic acid biosynthetic pathway a mathematical model was made for bacterial growth to describe the synergistic effect between sulfamethoxazole and trimethoprim. The results obtained show a strong synergism at growth inhibiting concentrations of these two drugs. Two cyclic pathways included in the model are responsible for this synergism. The roles of these pathways in producing ...
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ژورنال
عنوان ژورنال: Science
سال: 1977
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.897672